Description

Dosage can be increased under medical supervision according to the severity of the pain and the patient’s previous history of analgesic requirements.

Special populations:

Reductions in dosage may be appropriate in the elderly, and in patients with chronic hepatic disease (for acute hepatic disease see section 4.3), renal impairment, severe hypothyroidism, adrenocortical insufficiency, prostatic hypertrophy, shock, or where sedation is undesirable.

Discontinuation of therapy

Prior to starting treatment with opioids, a discussion should be held with patients to put in place a strategy for ending treatment with Morphine Oral Solution in order to minimize the risk of addiction and drug withdrawal syndrome.

Method of Administration For oral use.

When patients are transferred from other morphine preparations to Morphine Oral Solution dosage titration may be appropriate.

Morphine Sulfate is readily absorbed from the gastrointestinal tract following oral administration. However, when Morphine Oral Solution is used in place of parenteral morphine, a 50% to 100% increase in dosage is usually required in order to achieve the same level of analgesia.